Enhanced detection of the pathogenic prion protein by its supramolecular association with para-sulfonato-calix[n]arene derivatives

被引：25

作者：

Coleman, Anthony W.

Perret, Florent

Cecillon, Sebastien

Moussa, Aly

Martin, Ambroise

Dupin, Maryline

Perron, Herve

机构：

[1] Univ Lyon 1, IBCP, CNRS, UMR 5086, F-69367 Lyon, France

[2] Agcy Francaise Secur Sanit Aliments, F-69364 Lyon, France

[3] Univ Lyon 1, F-69373 Lyon, France

[4] R&D Neurol Dis, Biomerieux Adv Technol Unit, F-69280 Marcy Letoile, France

来源：

NEW JOURNAL OF CHEMISTRY | 2007年 / 31卷 / 05期

关键词：

D O I：

10.1039/b615523p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The supramolecular interaction between the pathogenic form of the prion protein and derivatives of the para-sulfonato-calix[n] arenes has been demonstrated and two putative binding sites determined; this interaction leads to an amplification of the Western Blot immunological detection of the prion protein by the SAF84 antibody.

引用

收藏

页码：711 / 717

页数：7

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