Functional coherence of the human Y chromosome

被引：677

作者：

Lahn, BT

Page, DC

机构：

[1] MIT,WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02142

来源：

SCIENCE | 1997年 / 278卷 / 5338期

关键词：

D O I：

10.1126/science.278.5338.675

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A systematic search of the nonrecombining region or the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full-length complementary DNA sequences. All 12 genes, and six of eight NRY genes or families previously isolated by less systematic means, fell into two classes. Genes in the first group were expressed in many organs; these housekeeping genes have X homologs that escape X inactivation. The second group, consisting of Y-chromosomal gene families expressed specifically in testes, may account for infertility among men with Y deletions. The coherence of the NRY's gene content contrasts with the apparently haphazard content of most eukaryotic chromosomes.

引用

收藏

页码：675 / 680

页数：8

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