Glial calcium: Homeostasis and signaling function

被引:561
作者
Verkhratsky, A [1 ]
Orkand, RK
Kettenmann, H
机构
[1] Max Delbruck Ctr Mol Med, Dept Cellular Neurosci, Berlin, Germany
[2] Univ Puerto Rico, Inst Neurobiol, San Juan, PR 00901 USA
关键词
D O I
10.1152/physrev.1998.78.1.99
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Glial cells respond to various electrical, mechanical, and chemical stimuli, including neurotransmitters, neuromodulators, and hormones, with an increase in intracellular Ca2+ concentration ([Ca2+](i)). The increases exhibit a variety of temporal and spatial patterns. These [Ca2+](i) responses result from the coordinated activity of a number of molecular cascades responsible for Ca2+ movement into or out of the cytoplasm either by way of the extracellular space or intracellular stores. Transplasmalemmal Ca2+ movements may be controlled by several types of voltage-and ligand-gated Ca2+-permeable channels as well as Ca2+ pumps and a Na+/Ca2+ exchanger. In addition, glial cells express various metabotropic receptors coupled to intracellular Ca2+ stores through the intracellular messenger inositol 1,4,5-trisphosphate. The interplay of different molecular cascades enables the development of agonist-specific patterns of Ca2+ responses. Such agonist specificity may provide a means for intracellular and intercellular information coding. Calcium signals can traverse gal, junctions between glial cells without decrement. These waves can serve as a substrate for integration of glial activity. By controlling gap junction conductance, Ca2+ waves may define the limits of functional glial networks. Neuronal activity can trigger [Ca2+](i) signals in apposed glial cells, and moreover, there is some evidence that glial [Ca2+](i) waves can affect neurons. Glial Ca2+ signaling can be regarded as a form of glial excitability.
引用
收藏
页码:99 / 141
页数:43
相关论文
共 465 条
[41]   GLUTAMATE AND GABA RECEPTORS IN VERTEBRATE GLIAL-CELLS [J].
BLANKENFELD, GV ;
KETTENMANN, H .
MOLECULAR NEUROBIOLOGY, 1991, 5 (01) :31-43
[42]   PHYSIOLOGICAL ROLES OF THE SODIUM-CALCIUM EXCHANGER IN NERVE AND MUSCLE [J].
BLAUSTEIN, MP ;
GOLDMAN, WF ;
FONTANA, G ;
KRUEGER, BK ;
SANTIAGO, EM ;
STEELE, TD ;
WEISS, DN ;
YAROWSKY, PJ .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 639 :254-274
[43]   IDENTIFICATION OF A FAMILY OF MUSCARINIC ACETYLCHOLINE-RECEPTOR GENES [J].
BONNER, TI ;
BUCKLEY, NJ ;
YOUNG, AC ;
BRANN, MR .
SCIENCE, 1987, 237 (4814) :527-532
[44]   THE ELEMENTAL PRINCIPLES OF CALCIUM SIGNALING [J].
BOOTMAN, MD ;
BERRIDGE, MJ .
CELL, 1995, 83 (05) :675-678
[45]   MOBILIZATION OF INTRACELLULAR CALCIUM BY SUBSTANCE-P IN A HUMAN ASTROCYTOMA CELL-LINE (U-373 MG) [J].
BORDEY, A ;
FELTZ, P ;
TROUSLARD, J .
GLIA, 1994, 11 (03) :277-283
[46]   AMPA KAINATE RECEPTOR ACTIVATION IN MURINE OLIGODENDROCYTE PRECURSOR CELLS LEADS TO ACTIVATION OF A CATION CONDUCTANCE, CALCIUM INFLUX AND BLOCKADE OF DELAYED RECTIFYING K+ CHANNELS [J].
BORGES, K ;
OHLEMEYER, C ;
TROTTER, J ;
KETTENMANN, H .
NEUROSCIENCE, 1994, 63 (01) :135-149
[47]   ADULT-RAT OPTIC-NERVE OLIGODENDROCYTE PROGENITOR CELLS EXPRESS A DISTINCT REPERTOIRE OF VOLTAGE-GATED AND LIGAND-GATED ION CHANNELS [J].
BORGES, K ;
WOLSWIJK, G ;
OHLEMEYER, C ;
KETTENMANN, H .
JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 40 (05) :591-605
[48]   EXCITATORY AMINO-ACIDS DIRECTLY DEPOLARIZE RAT-BRAIN ASTROCYTES IN PRIMARY CULTURE [J].
BOWMAN, CL ;
KIMELBERG, HK .
NATURE, 1984, 311 (5987) :656-659
[49]   PHYSIOLOGY OF TRANSFORMED GLIAL-CELLS [J].
BRISMAR, T .
GLIA, 1995, 15 (03) :231-243
[50]   FUNCTIONAL PAF RECEPTORS IN GLIA CELLS - BINDING PARAMETERS AND REGULATION OF EXPRESSION [J].
BRODIE, C .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1994, 12 (07) :631-640