Chemically immobilized single-stranded oligonucleotides on praseodymium oxide nanoparticles as an unlabeled DNA sensor probe using impedance

被引：26

作者：

Shrestha, Sudha

Yeung, Connie M. Y.

Mills, Catherine E.

Lewington, Jay

Tsang, Shik Chi ^{[1
]}

机构：

[1] Univ Reading, Sch Chem, Surface & Catalysis Res Ctr, Reading RG6 6AD, Berks, England

[2] Smiths Detect, Watford WD23 2BW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 21期

关键词：

DNA structures; electrochemistry; label-free reagents; praseodymium oxide; surface chemistry;

D O I：

10.1002/anie.200604827

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A spark of attraction: Ellipsoidal Pr6O11 particles on indium tin oxide (ITO) modified with single-stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is not obtained upon the addition of an oligonucleotide with slightly mismatched bases. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3855 / 3859

页数：5

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