Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

被引：39

作者：

Vecchione, Matthew K. ^{[1
]}

Li, Le ^{[1
]}

Seidel, Daniel ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 25期

关键词：

AMINO ACID-DERIVATIVES; QUATERNARY AMMONIUM-SALTS; ASYMMETRIC-SYNTHESIS; CINCHONA ALKALOIDS; NONADJACENT STEREOCENTERS; CONJUGATE ADDITION; EFFICIENT APPROACH; CYCLIC-PEPTIDES; BOND DONORS; SCHIFF-BASE;

D O I：

10.1039/c0cc00556h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A readily available bifunctional thiourea catalyst promotes aldol additions of alpha-isothiocyanato imides to alpha-ketoesters under mild reaction conditions to form beta-hydroxy-alpha-amino acid derivatives with high levels of enantioselectivity.

引用

页码：4604 / 4606

页数：3

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