The structural basis of glycosidase inhibition by five-membered iminocyclitols:: The clan a glycoside hydrolase endoglycoceramidase as a model system

被引：36

作者：

Caines, Matthew E. C.

Hancock, Susan M.

Tarling, Chris A.

Wrodnigg, Tanja M.

Stick, Robert V.

Stuetz, Arnold E.

Vasella, Andrea

Withers, Stephen G.

Strynadka, Natalie C. J.

机构：

[1] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z3, Canada

[3] Graz Univ Technol, Inst Organ Chem, A-8010 Graz, Austria

[4] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Crawley, WA 6009, Australia

[5] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

carbohydrates; drug design; glycosidases; iminocyclitols; inhibitors;

D O I：

10.1002/anie.200700268

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fitting five into six: The crystal structure of a glycosidase-bound, flve-membered iminocyclitol inhibitor was determined (see picture), and its binding interactions were compared to those of the classical six-membered iminocyclitol inhibitors isofagomine and glucoimidazole and of the glycosyl-enzyme intermediate. This information may be used to develop more potent and specific therapeutically useful glycosidase inhibitors. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4474 / 4476

页数：3

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