Methods for labeling quantum dots to biomolecules

被引：19

作者：

Lin, ZB

Su, XG

Mu, Y

Jin, QH ^{[1
]}

机构：

[1] Jilin Univ, Inst Micro Analyt Instrumentat, Coll Chem, Changchun 130023, Peoples R China

[2] Jilin Univ, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130023, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2004年 / 4卷 / 06期

关键词：

quantum dots; labeling method; biomolecules;

D O I：

10.1166/jnn.2004.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Semiconductor quantum dots (QDs) are thought to be the most promising fluorescent probe for biological and biomedical applications because of their unique size-dependent optical and electronic properties. QD bioconjugates provide important advantages over conventional organic dyes. This review compares the optical properties of nanoparticles and dyes and describes the surface modification of the QDs and the methods for biomolecules conjugating to QDs. In addition, the effect of QDs on normal physiology in real biological applications is discussed.

引用

收藏

页码：641 / 645

页数：5

相关论文

共 40 条

[1] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[2]

BOWENKATARI JE, 1994, J PHYS CHEM-US, V98, P4109

[3] Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

[4] Luminescent quantum dots for multiplexed biological detection and imaging [J].

Chan, WCW ;

Maxwell, DJ ;

Gao, XH ;

Bailey, RE ;

Han, MY ;

Nie, SM .

CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :40-46

[5] Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].

Chan, WCW ;

Nie, SM .

SCIENCE, 1998, 281 (5385) :2016-2018

[6] In vivo imaging of quantum dots encapsulated in phospholipid micelles [J].

Dubertret, B ;

Skourides, P ;

Norris, DJ ;

Noireaux, V ;

Brivanlou, AH ;

Libchaber, A .

SCIENCE, 2002, 298 (5599) :1759-1762

[7] Strongly photoluminescent CdTe nanocrystals by proper surface modification [J].

Gao, MY ;

Kirstein, S ;

Möhwald, H ;

Rogach, AL ;

Kornowski, A ;

Eychmüller, A ;

Weller, H .

JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (43) :8360-8363

[8] Thiol-capping of CdTe nanocrystals:: An alternative to organometallic synthetic routes [J].

Gaponik, N ;

Talapin, DV ;

Rogach, AL ;

Hoppe, K ;

Shevchenko, EV ;

Kornowski, A ;

Eychmüller, A ;

Weller, H .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (29) :7177-7185

[9] Sorting fluorescent nanocrystals with DNA [J].

Gerion, D ;

Parak, WJ ;

Williams, SC ;

Zanchet, D ;

Micheel, CM ;

Alivisatos, AP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (24) :7070-7074

[10] Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots [J].

Gerion, D ;

Pinaud, F ;

Williams, SC ;

Parak, WJ ;

Zanchet, D ;

Weiss, S ;

Alivisatos, AP .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (37) :8861-8871

← 1 2 3 4 →