Francisella tularensis has a significant extracellular phase in infected mice

被引：95

作者：

Forestal, Colin A.

Malik, Meenakshi

Catlett, Sally V.

Savitt, Anne G.

Benach, Jorge L.

Sellati, Timothy J.

Furie, Martha B. ^{[1
]}

机构：

[1] SUNY Stony Brook, Ctr Infect Dis, Stony Brook, NY 11794 USA

[2] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany, NY USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷 / 01期

关键词：

D O I：

10.1086/518611

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of Francisella tularensis to replicate in macrophages has led many investigators to assume that it resides primarily intracellularly in the blood of mammalian hosts. We have found this supposition to be untrue. In almost all cases, the majority of F. tularensis recovered from the blood of infected mice was in plasma rather than leukocytes. This distribution was observed irrespective of size of inoculum, route of inoculation, time after inoculation, or virulence of the infecting strain. Our findings yield new insight into the pathogenesis of tularemia and may have important ramifications in the search for anti-Francisella therapies.

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页码：134 / 137

页数：4

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