TACI and BAFF-R mediate isotype switching in B cells

被引：412

作者：

Castigli, E

Wilson, SA

Scott, S

Dedeoglu, F

Xu, SL

Lam, KP

Bram, RJ

Jabara, H

Geha, RS ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Div Immunol, Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Inst Mol & Cell Biol, Singapore 117609, Singapore

[4] Mayo Clin & Mayo Grad Sch Med, Dept Immunol, Rochester, MN 55905 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 01期

关键词：

D O I：

10.1084/jem.20032000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

引用

收藏

页码：35 / 39

页数：5

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