DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

被引：990

作者：

Litinskiy, MB

Nardelli, B

Hilbert, DM

He, B

Schaffer, A

Casali, P

Cerutti, A

机构：

[1] Cornell Univ, Div Mol Immunol, Dept Pathol & Lab Med, Joan & Sanford L Weill Med Coll, New York, NY 10021 USA

[2] Human Genome Sci, Rockville, MD 20850 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 09期

关键词：

D O I：

10.1038/ni829

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We show here that dendritic cells upregulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand. In the presence of interleukin 10 (IL-10) or transforming growth factor-beta, BLyS and APRIL induce CSR from C to C and/or C-alpha genes in B cells, whereas CSR to C-epsilon requires IL-4. Secretion of class-switched antibodies requires additional stimulation by B cell antigen receptor engagement and IL-15. By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.

引用

页码：822 / 829

页数：8

共 50 条

[1]

ARMITAGE RJ, 1995, J IMMUNOL, V154, P483

[2] GENERATION OF MEMORY B-CELLS AND PLASMA-CELLS IN-VITRO [J].

ARPIN, C ;

DECHANET, J ;

VANKOOTEN, C ;

MERVILLE, P ;

GROUARD, G ;

BRIERE, F ;

BANCHEREAU, J ;

LIU, YJ .

SCIENCE, 1995, 268 (5211) :720-722

[3] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[4] The mechanism and regulation of chromosomal V(D)J recombination [J].

Bassing, CH ;

Swat, W ;

Alt, FW .

CELL, 2002, 109 :S45-S55

[5] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[6] CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells [J].

Cerutti, A ;

Schaffer, A ;

Shah, S ;

Zan, H ;

Liou, HC ;

Goodwin, RG ;

Casali, P .

IMMUNITY, 1998, 9 (02) :247-256

[7]

Cerutti A, 1998, J IMMUNOL, V160, P2145

[8] Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells [J].

Cerutti, A ;

Kim, EC ;

Shah, S ;

Schattner, EJ ;

Zan, H ;

Schaffer, A ;

Casali, P .

NATURE IMMUNOLOGY, 2001, 2 (02) :150-156

[9] B cells on the front line [J].

Cyster, JG .

NATURE IMMUNOLOGY, 2000, 1 (01) :9-10

[10] Germinal centers without T cells [J].

de Vinuesa, CG ;

Cook, MC ;

Ball, J ;

Drew, M ;

Sunners, Y ;

Cascalho, M ;

Wabl, M ;

Klaus, GGB ;

MacLennan, ICM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (03) :485-493

← 1 2 3 4 5 →