Identification, sequence, and expression of caveolin-2 defines a caveolin gene family

被引：492

作者：

Scherer, PE

Okamoto, T

Chun, MY

Nishimoto, I

Lodish, HF

Lisanti, MP

机构：

[1] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,SHRINERS HOSP CRIPPLED CHILDREN,DEPT ANESTHESIA,BOSTON,MA 02114

[3] MASSACHUSETTS GEN HOSP E,CARDIOVASC RES CTR,DEPT MED,BOSTON,MA 02129

[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 01期

关键词：

D O I：

10.1073/pnas.93.1.131

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes, Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity, Here, an approximate to 20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte-derived caveolin-enriched membranes; caveolin was retermed caveolin-1, Caveolins 1 and 2 are similar in most respects. mRNAs for both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae, However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.

引用

页码：131 / 135

页数：5

共 28 条

[21] INDUCTION OF CAVEOLIN DURING ADIPOGENESIS AND ASSOCIATION OF GLUT4 WITH CAVEOLIN-RICH VESICLES [J].