Asymmetric synthesis of 3-substituted pyrrolidones via α-alkylation of a chiral non-racemic γ-lactam

被引：29

作者：

Baussanne, I ^{[1
]}

Travers, C ^{[1
]}

Royer, J ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(98)00024-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Alkyl pyrrolidones 9 were synthesized in good yield and high diastereoselectivity by oc-alkylation of the new chiral non-racemic lactam 8 derived from (R)-(-)-phenylglycinol. After debenzylation and introduction of an electron-withdrawing group, 3-methylpyrrolidone 10 is easily hydrolyzed in a basic medium to produce gamma-aminobutyric acid (GABA) analogue 13. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：797 / 804

页数：8

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