The fourth helical secondary structure of β-peptides:: The (P)-28-helix of a β-hexapeptide consisting of (2R,3S)-3-amino-2-hydroxy acid residues

被引：88

作者：

Gademann, K ^{[1
]}

Häne, A ^{[1
]}

Rueping, M ^{[1
]}

Jaun, B ^{[1
]}

Seebach, D ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 13期

关键词：

amino acids; beta-peptides; conformational analysis; peptidomimetics; secondary structure;

D O I：

10.1002/anie.200250290

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Small change with great effect! An oligomer of α-hydroxy-β-amino acids folds into a right-handed helical structure (see picture) in MeOH; in contrast, the methyl analogue has a pleated sheet structure. Including this new helix, four different helical secondary structures of β-peptides have been discovered - a structural diversity that should allow the generation of elaborate proteomimetics.

引用

页码：1534 / 1537

页数：4

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