Tyrosinase inhibitor isolated from the leaves of Zanthoxylum piperitum

被引：52

作者：

Jeong, CH

Shim, KH ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Div Appl Life Sci, Grad Sch, Jinju 660701, South Korea

[2] Gyeongsang Natl Univ, Inst Agr Life Sci, Jinju 660701, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 09期

关键词：

Zanthoxylum piperitum; quercetin; quercitrin; tyrosinase; Streptomyces bikiniensis;

D O I：

10.1271/bbb.68.1984

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two flavonols, quercetin (1) and quercitrin (2), were isolated from the leaves of Zanthoxylum piperitum. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods. Quercetin showed significant inhibition against mushroom tyrosinase with an IC50 value of 3.8 mug/ml, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in a competitive manner (Ki = 10 +/- 0.20 muM) when L-tyrosine was used as a substrate, although it did not inhibit the melanin production of Streptomyces bikiniensis.

引用

页码：1984 / 1987

页数：4

共 19 条

[1]

Baek Seung-Hwa, 2003, Korean Journal of Microbiology and Biotechnology, V31, P135

[2] Review of the biology of quercetin and related bioflavonoids [J].