No association of inducible nitric oxide synthase gene (NOS2A) to multiple sclerosis

被引：12

作者：

Blanco, Y

Yagüe, J

Graus, F

Saiz, A

机构：

[1] Hosp Clin Barcelona, Serv Neurol, E-08036 Barcelona, Spain

[2] Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain

来源：

JOURNAL OF NEUROLOGY | 2003年 / 250卷 / 05期

关键词：

multiple sclerosis; nitric oxide; NOS2A promoter;

D O I：

10.1007/s00415-003-1047-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nitric oxide (NO) is a nonspecific inflammatory mediator that has been involved in the pathogenesis of multiple sclerosis (MS). The influence of the promoter polymorphism of inducible NO synthase gene (NOS2A) on susceptibility and outcome was studied in 140 MS Spanish patients and 147 healthy controls matched for sex, age, and ethnicity. No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms.

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收藏

页码：598 / 600

页数：3

相关论文

共 15 条

[1]

Bellamy R, 1997, CLIN GENET, V52, P192

[2] 3 MEMBERS OF THE NITRIC-OXIDE SYNTHASE-II GENE FAMILY (NOS2A, NOS2B, AND NOS2C) COLOCALIZE TO HUMAN-CHROMOSOME-17 [J].

BLOCH, KD ;

WOLFRAM, JR ;

BROWN, DM ;

ROBERTS, JD ;

ZAPOL, DG ;

LEPORE, JJ ;

FILIPPOV, G ;

THOMA, JE ;

JACOB, HJ ;

BLOCH, DB .

GENOMICS, 1995, 27 (03) :526-530

[3] Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis [J].

Giovannoni, G .

MULTIPLE SCLEROSIS, 1998, 4 (01) :27-30

[4]

HILLERT J, 2001, HDB MULTIPLE SCLEROS, P33

[5] Genomewide scan of multiple sclerosis in Finnish multiplex families [J].

Kuokkanen, S ;

Gschwend, M ;

Rioux, JD ;

Daly, MJ ;

Terwilliger, JD ;

Tienari, PJ ;

Wikström, J ;

Palo, J ;

Stein, LD ;

Hudson, TJ ;

Lander, ES ;

Peltonen, L .

AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (06) :1379-1387

[6] Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions [J].

Liu, JSH ;

Zhao, ML ;

Brosnan, CF ;

Lee, SC .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (06) :2057-2066

[7] Defining the clinical course of multiple sclerosis: Results of an international survey [J].

Lublin, FD ;

Reingold, SC .

NEUROLOGY, 1996, 46 (04) :907-911

[8] No linkage or association of the nitric oxide synthase genes to multiple sclerosis [J].

Modin, H ;

Dai, Y ;

Masterman, T ;

Svejgaard, A ;

Sorensen, PS ;

Oturai, A ;

Ryder, LP ;

Spurkland, A ;

Vartdal, F ;

Laaksonen, M ;

Sandberg-Wollheim, M ;

Myhr, KM ;

Nyland, H ;

Hillert, J .

JOURNAL OF NEUROIMMUNOLOGY, 2001, 119 (01) :95-100

[9] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[10] A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22 [J].

Sawcer, S ;

Jones, HB ;

Feakes, R ;

Gray, J ;

Smaldon, N ;

Chataway, J ;

Robertson, N ;

Clayton, D ;

Goodfellow, PN ;

Compston, A .

NATURE GENETICS, 1996, 13 (04) :464-468