No association of inducible nitric oxide synthase gene (NOS2A) to multiple sclerosis

被引：12

作者：

Blanco, Y

Yagüe, J

Graus, F

Saiz, A

机构：

[1] Hosp Clin Barcelona, Serv Neurol, E-08036 Barcelona, Spain

[2] Univ Barcelona, Hosp Clin, IDIBAPS, Barcelona, Spain

来源：

JOURNAL OF NEUROLOGY | 2003年 / 250卷 / 05期

关键词：

multiple sclerosis; nitric oxide; NOS2A promoter;

D O I：

10.1007/s00415-003-1047-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nitric oxide (NO) is a nonspecific inflammatory mediator that has been involved in the pathogenesis of multiple sclerosis (MS). The influence of the promoter polymorphism of inducible NO synthase gene (NOS2A) on susceptibility and outcome was studied in 140 MS Spanish patients and 147 healthy controls matched for sex, age, and ethnicity. No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms.

引用

页码：598 / 600

页数：3

共 15 条

[11] Association of interleukin-1β and interleukin-1 receptor antagonist genes with disease severity in MS [J].