Retroviral integrase inhibitors year 2000: update and perspectives

被引：98

作者：

Pommier, Y ^{[1
]}

Marchand, C ^{[1
]}

Neamati, N ^{[1
]}

机构：

[1] NCI, Div Basic Sci, Mol Pharmacol Lab, Bethesda, MD 20892 USA

来源：

ANTIVIRAL RESEARCH | 2000年 / 47卷 / 03期

基金：

美国国家卫生研究院;

关键词：

retroviruses; integrase inhibitors; resistance; structure of integrases;

D O I：

10.1016/S0166-3542(00)00112-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

HIV-1 integrase is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. A number of inhibitors have been reported in the past 8 years. This review focuses on the recent developments in the past 2 years. There are now several inhibitors with known sites of actions and antiviral activity. The challenge is to convert these leads into drugs that will selectively target integrase in vivo, and can be added to our antiviral armamentarium. (C) 2000 Published by Elsevier Science B.V.

引用

页码：139 / 148

页数：10

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