Knitting complex weaves with DNA origami

被引：102

作者：

Shih, William M. ^{[1
,2
,3
]}

Lin, Chenxiang ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Wyss Inst Biologically Inspired Engn Harvard, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2010年 / 20卷 / 03期

关键词：

FOLDING DNA; DIRECTED NUCLEATION; NANOSCALE SHAPES; TILES; ACID; DESIGN; NANOSTRUCTURES; NANOTECHNOLOGY; NANOPARTICLES; MOLECULES;

D O I：

10.1016/j.sbi.2010.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past three decades have witnessed steady growth in our ability to harness DNA branched junctions as building blocks for programmable self-assembly of diverse supramolecular architectures. The DNA-origami method, which exploits the availability of long DNA sequences to template sophisticated nanostructures, has played a major role in extending this trend through the past few years. Today, two-dimensional and three-dimensional custom-shaped nanostructures comparable in mass to a small virus can be designed, assembled, and characterized with a prototyping cycle on the order of a couple of weeks.

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页码：276 / 282

页数：7

相关论文

共 48 条

[1] DNA origami design of dolphin-shaped structures with flexible tails [J].

Andersen, Ebbe S. ;

Dong, Mingdong ;

Nielsen, Morten M. ;

Jahn, Kasper ;

Lind-Thomsen, Allan ;

Mamdouh, Wael ;

Gothelf, Kurt V. ;

Besenbacher, Flemming ;

Kjems, Jorgen .

ACS NANO, 2008, 2 (06) :1213-1218

[2] Self-assembly of a nanoscale DNA box with a controllable lid [J].

Andersen, Ebbe S. ;

Dong, Mingdong ;

Nielsen, Morten M. ;

Jahn, Kasper ;

Subramani, Ramesh ;

Mamdouh, Wael ;

Golas, Monika M. ;

Sander, Bjoern ;

Stark, Holger ;

Oliveira, Cristiano L. P. ;

Pedersen, Jan Skov ;

Birkedal, Victoria ;

Besenbacher, Flemming ;

Gothelf, Kurt V. ;

Kjems, Jorgen .

NATURE, 2009, 459 (7243) :73-U75

[3] An information-bearing seed for nucleating algorithmic self-assembly [J].

Barish, Robert D. ;

Schulman, Rebecca ;

Rothemund, Paul W. K. ;

Winfree, Erik .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (15) :6054-6059

[4] Recent Progress Toward the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers [J].

Brudno, Yevgeny ;

Liu, David R. .

CHEMISTRY & BIOLOGY, 2009, 16 (03) :265-276

[5] Folding DNA into Twisted and Curved Nanoscale Shapes [J].

Dietz, Hendrik ;

Douglas, Shawn M. ;

Shih, William M. .

SCIENCE, 2009, 325 (5941) :725-730

[6] DNA-nanotube-induced alignment of membrane proteins for NMR structure determination [J].

Douglas, Shawn M. ;

Chou, James J. ;

Shih, William M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (16) :6644-6648

[7] Rapid prototyping of 3D DNA-origami shapes with caDNAno [J].

Douglas, Shawn M. ;

Marblestone, Adam H. ;

Teerapittayanon, Surat ;

Vazquez, Alejandro ;

Church, George M. ;

Shih, William M. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (15) :5001-5006

[8] Self-assembly of DNA into nanoscale three-dimensional shapes [J].

Douglas, Shawn M. ;

Dietz, Hendrik ;

Liedl, Tim ;

Hoegberg, Bjoern ;

Graf, Franziska ;

Shih, William M. .

NATURE, 2009, 459 (7245) :414-418

[9] Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure [J].

Endo, Masayuki ;

Katsuda, Yousuke ;

Hidaka, Kumi ;

Sugiyama, Hiroshi .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (05) :1592-1597

[10] DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms [J].

Endo, Masayuki ;

Hidaka, Kumi ;

Kato, Takayuki ;

Namba, Keiichi ;

Sugiyama, Hiroshi .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (43) :15570-+

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