Neurochemistry and neuropharmacology of emesis - the role of serotonin

被引：74

作者：

Endo, T ^{[1
]}

Minami, M

Hirafuji, M

Ogawa, T

Akita, K

Nemoto, M

Saito, H

Yoshioka, M

Parvez, SH

机构：

[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Dept Pharmacol, Ishikari, Hokkaido 0610293, Japan

[2] Japanese Red Cross Hokkaido Coll Nursing, Dept Basic Sci, Kitami, Hokkaido 0900011, Japan

[3] Hokkaido Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 0608638, Japan

[4] Univ Reims, F-51687 Reims 2, France

来源：

TOXICOLOGY | 2000年 / 153卷 / 1-3期

关键词：

emesis; 5-HT; 5-HT3; receptor; 5-HT4; 5-HT release; vagal afferent nerve;

D O I：

10.1016/S0300-483X(00)00314-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Emesis is an instinctive defense reaction caused by the somato-autonomic nerve reflex which is integrated in the medulla oblongata. Emesis caused by cytotoxic drugs and radiation is associated with an increase in the concentration of 5-hydroxytryptamine (5-HT) in the intestinal mucosa and in the brainstem. 5-HT released from enterochromaffin (EC) cells, which synthesize and secrete 5-HT, stimulates the 5-HT, receptors on the adjacent vagal afferent nerves. This vagal afferent nerve depolarization may evoke the vomiting reflex. This review describes the role of 5-HT in anticancer drug-induced emesis from the viewpoint of 5-HT release from EC cells and afferent vagus nerve activity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：189 / 201

页数：13

共 90 条

[81] ENANTIOSELECTIVE INHIBITION OF APOMORPHINE-INDUCED EMESIS IN THE FERRET BY THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994 [J].