An imine addition/ring-closing metathesis approach to the spirocyclic core of halichlorine and pinnaic acid

被引:163
作者
Wright, DL [1 ]
Schulte, JP [1 ]
Page, MA [1 ]
机构
[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA
关键词
D O I
10.1021/ol005903b
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An approach to the spirocyclic core of halichlorine and pinnaic acid has been designed around an imine allylation/ring-closing metathesis sequence. This sequence has been used to generate several azabicylo[n.5] model systems. A newly reported metathesis catalyst was show to be highly effective for cyclization of these systems.
引用
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页码:1847 / 1850
页数:4
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