Extracellular BMP-antagonist regulation in development and disease: tied up in knots

被引：198

作者：

Walsh, David W. ^{[1
]}

Godson, Catherine ^{[1
]}

Brazil, Derek P. ^{[3
]}

Martin, Finian ^{[2
]}

机构：

[1] Univ Coll Dublin, Sch Med & Med Sci, Conway Inst, Dublin 4, Ireland

[2] Univ Coll Dublin, Sch Biomol & Biomed Sci, Conway Inst, Dublin 4, Ireland

[3] Queens Univ, Ctr Vis & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland

来源：

TRENDS IN CELL BIOLOGY | 2010年 / 20卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

BONE MORPHOGENETIC PROTEIN; SENSITIZATION-ASSOCIATED GENE-1; EMBRYONIC STEM-CELLS; TWISTED-GASTRULATION; TGF-BETA; DIABETIC-NEPHROPATHY; RENAL FIBROSIS; OSTEOBLASTIC DIFFERENTIATION; MESENCHYMAL TRANSITION; MALIGNANT-MELANOMA;

D O I：

10.1016/j.tcb.2010.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Developmental processes are regulated by the bone morphogenetic protein (BMP) family of secreted molecules. BMPs bind to serine/threonine kinase receptors and signal through the canonical Smad pathway and other intracellular effectors. Integral to the control of BMPs is a diverse group of secreted BMP antagonists that bind to BMPs and prevent engagement with their cognate receptors. Tight temporospatial regulation of both BMP and BMP-antagonist expression provides an exquisite control system for developing tissues. Additional facets of BMP-antagonist biology, such as crosstalk with Wnt and Sonic hedgehog signaling during development, have been revealed in recent years. In addition, previously unappreciated roles for the BMP antagonists in kidney fibrosis and cancer have been elucidated. This review provides a description of BMP-antagonist biology, together with highlights of recent novel insights into the role of these antagonists in development, signal transduction and human disease.

引用

页码：244 / 256

页数：13

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