Interference with lectin binding and bacterial adhesion by multivalent carbohydrates and peptidic carbohydrate mimics

被引：40

作者：

Pieters, RJ ^{[1
]}

机构：

[1] Univ Utrecht, Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 2004年 / 16卷 / 90期

关键词：

multivalent carbohydrates; glycodendrimers; galectins; anti-adhesion; carbohydrate mimicry;

D O I：

10.4052/tigg.16.243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considering the importance of protein-carbohydrate interactions in biological processes, effective interference with these interactions may prove to be a powerful way towards novel therapeutics. Multivalency is an important principle that characterizes these interactions and is likely a required design principle for the synthesis of molecules with the goal to interfere effectively. Glycodendrimer synthesis is described here along with interference with animal, plant and bacterial lectins. Large affinity enhancements due to multivalency were observed in selected cases. Initial studies with peptide sequences as interfering moieties in protein carbohydrate interactions are also described which yield ligands in the milimolar range.

引用

页码：243 / 254

页数：12

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