Involvement of Members of the Cadherin Superfamily in Cancer

被引：548

作者：

Berx, Geert ^{[1
,2
]}

van Roy, Frans ^{[1
,3
]}

机构：

[1] Univ Ghent, Dept Biomed Mol Biol, B-9000 Ghent, Belgium

[2] VIB, Mol & Cellular Oncol Unit, Dept Mol Biomed Res, Ghent, Belgium

[3] VIB, Mol Cell Biol Unit, Dept Mol Biomed Res, Ghent, Belgium

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2009年 / 1卷 / 06期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; DIFFUSE GASTRIC-CANCER; HUMAN BREAST-CANCER; CELL-CELL-ADHESION; CANDIDATE TUMOR-SUPPRESSOR; ANCHORED T-CADHERIN; HUMAN HEPATOCELLULAR-CARCINOMA; HUMAN-MELANOMA CELLS; MOLECULE E-CADHERIN; PROSTATE-CANCER;

D O I：

10.1101/cshperspect.a003129

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

We review the role of cadherins and cadherin-related proteins in human cancer. Cellular and animal models for human cancer are also dealt with whenever appropriate. E-cadherin is the prototype of the large cadherin superfamily and is renowned for its potent malignancy suppressing activity. Different mechanisms for inactivating E-cadherin/CDH1 have been identified in human cancers: inherited and somatic mutations, aberrant protein processing, increased promoter methylation, and induction of transcriptional repressors such as Snail and ZEB family members. The latter induce epithelial mesenchymal transition, which is also associated with induction of "mesenchymal" cadherins, a hallmark of tumor progression. VE-cadherin/CDH5 plays a role in tumor-associated angiogenesis. The atypical T-cadherin/CDH13 is often silenced in cancer cells but up-regulated in tumor vasculature. The review also covers the status of protocadherins and several other cadherin-related molecules in human cancer. Perspectives for emerging cadherin-related anticancer therapies are given.

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页数：27

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