Wnt signaling: why is everything so negative?

被引：99

作者：

Brown, JD

Moon, RT

机构：

[1] Univ Washington, Howard Hughes Med Inst, Dept Pharmacol, Seattle, WA 98195 USA

[2] Univ Washington, Howard Hughes Med Inst, Program Mol & Cellular Biol, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(98)80140-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Wnt proteins constitute a family of secreted glycoproteins the members of which have essential signaling roles during embryogenesis. The recent identification of several new regulators of this signal transduction pathway have revealed unexpectedly intricate levels of constraint on Wnt-dependent gene activation, and studies in developing embryos and in cell culture systems have allowed a more complete understanding of the functional and biochemical interactions between components of this evolutionarily conserved pathway. (C) Current Biology Ltd ISSN 0955-0674.

引用

页码：182 / 187

页数：6

共 64 条

[31] Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus [J].