Comparative biology of the endocannabinoid system - Possible role in the immune response

被引：91

作者：

Salzet, M

Breton, C

Bisogno, T

Di Marzo, V

机构：

[1] Univ Sci & Technol Lille, Lab Endocrinol Annelides, CNRS, UPRESA 8017, F-59650 Villeneuve Dascq, France

[2] Arco Felice, Ist Clin Mol Interesse Biol, Naples, Italy

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2000年 / 267卷 / 16期

关键词：

cannabinoids; anandamide; 2-arachidonoylglycerol; immune response; nitric oxide; invertebrates;

D O I：

10.1046/j.1432-1327.2000.01550.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review we discuss data showing that the endogenous cannabinoid system, represented by cannabinoid receptors, endogenous cannabinoid receptor ligands and enzymes for the biosynthesis and degradation of these ligands, is conserved throughout evolution from coelenterates to man. This signaling system has been suggested to play several roles in animals, including the regulation of cell development and growth, nervous functions, reproduction and feeding behavior. In this article, however, we shall describe with more detail the possible function of the endogenous cannabinoid system in the modulation of immune response in organisms from the lower to the higher levels of animal evolution.

引用

页码：4917 / 4927

页数：11

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