The implementation of the sentinel node biopsy as a routine procedure for patients with breast cancer

被引:80
作者
Rahusen, FD
Pijpers, R
van Diest, PJ
Bleichrodt, RP
Torrenga, H
Meijer, S
机构
[1] Free Univ Amsterdam Hosp, Dept Surg Oncol, NL-1007 MB Amsterdam, Netherlands
[2] Free Univ Amsterdam Hosp, Dept Nucl Med, NL-1007 MB Amsterdam, Netherlands
[3] Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands
关键词
D O I
10.1067/msy.2000.107229
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. The sentinel node procedure for breast cancer allows for accurate staging of the axilla while the axillary node dissection can be avoided in patients with no sentinel node metastasis. This study describes those patients in whom an axillary dissection is performed, depending on the outcome of the sentinel node procedure: with particular emphasis on the use of strict criteria for the procedure and its practical limitations. Methods, Preoperative lymphoscintigraphy was Performed in 115 consecutive patients The sentinel nodes were located with the use of a gamma probe and blue dye Axillary dissection was performed at the same time when the sentinel node procedure was positive by frozen section or not successful by the criteria used. Results. The sentinel node procedure was successful in 106 patients, with the sentinel node being both radioactive and blue in 94% of these patients. The frozen section was positive in 21 of 37 patients with sentinel node metastases. Axillary dissection could be avoided in 69 patients. Conclusions. The triple technique (with the use of lymphoscintigraphy, the gamma probe, and the blue dye) gives a high success rate of he sentinel node procedure even when strict criteria for a successful sentinel node procedure are used. Palpation of the open axilla for metastatic nonsentinel nodes is advocated.
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页码:6 / 12
页数:7
相关论文
共 40 条
[31]   Lymphoscintigraphy and feasibility of sentinel node biopsy in 83 patients with primary breast cancer [J].
Roumen, RMH ;
Valkenburg, JGM ;
Geuskens, LM .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1997, 23 (06) :495-502
[32]  
SACRE RA, 1986, EUR J SURG ONCOL, V12, P169
[33]   THE EFFICACY OF LOWER AXILLARY SAMPLING IN OBTAINING LYMPH-NODE STATUS IN BREAST-CANCER - A CONTROLLED RANDOMIZED TRIAL [J].
STEELE, RJC ;
FORREST, APM ;
GIBSON, T ;
STEWART, HJ ;
CHETTY, U .
BRITISH JOURNAL OF SURGERY, 1985, 72 (05) :368-369
[34]  
STRAND SE, 1989, CRIT REV THER DRUG, V6, P211
[35]   Sentinel node biopsy in 70 unselected patients with breast cancer: increased feasibility by using 10 mCi radiocolloid in combination with a blue dye tracer [J].
van der Ent, FWC ;
Kengen, RAM ;
van der Pol, HAG ;
Hoofwijk, AGM .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1999, 25 (01) :24-29
[36]   Pathological investigation of sentinel lymph nodes [J].
van Diest, PJ ;
Peterse, HL ;
Borgstein, PJ ;
Hoekstra, O ;
Meijer, CJLM .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1999, 26 (04) :S43-S49
[37]  
van Diest PJ, 1999, HISTOPATHOLOGY, V35, P14
[38]   Consequences of sentinel node in clinical decision making in breast cancer and prospects for future studies [J].
Veronesi, U ;
Zurrida, S ;
Galimberti, V .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1998, 24 (02) :93-95
[39]   Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes [J].
Veronesi, U ;
Paganelli, G ;
Galimberti, V ;
Viale, G ;
Zurrida, S ;
Bedoni, M ;
Costa, A ;
deCicco, C ;
Geraghty, JG ;
Luini, A ;
Sacchini, V ;
Veronesi, P .
LANCET, 1997, 349 (9069) :1864-1867
[40]   Radiopharmaceuticals in sentinel lymph-node detection - an overview [J].
Wilhelm, AJ ;
Mijnhout, GS ;
Franssen, EJF .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1999, 26 (04) :S36-S42