Efficient synthesis of thioesters and amides from aldehydes by using an intermolecular radical reaction in water

被引：57

作者：

Nambu, H ^{[1
]}

Hata, K ^{[1
]}

Matsugi, M ^{[1
]}

Kita, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 02期

关键词：

aldehydes; amidation; radical reactions; surfactants; thioesters;

D O I：

10.1002/chem.200400754

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of the water-soluble radical initiator, 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (VA-044) and the surfactant, cetyltrimethyl-ammonium bromide (CTAB), was found to be the most suitable condition for the effective and direct synthesis of useful active thioesters (pentafluorophenyl thioesters) in water. In addition, the direct amidation of aldehydes was achieved by the addition of the amines to the thioesterification reaction mixture in water.

引用

页码：719 / 727

页数：9

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