Cellular reaction to Mycobacterium avium complex (MAC) clinical isolates differing in hemolytic activity and virulence for C57BL/6 mice

被引：1

作者：

Brzychcy, M

Zwolska, Z

Andrzejczyk, Z

Rudnicka, W

机构：

[1] Univ Lodz, Dept Infect Biol, Inst Microbiol & Immunol, PL-90237 Lodz, Poland

[2] Inst TB & Lung Dis, Warsaw, Poland

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1998年 / 42卷 / 05期

关键词：

mycobacteria; hemolysis; macrophages; cytotoxic T cells;

D O I：

10.1111/j.1348-0421.1998.tb02295.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we showed that Mycobacterium avium complex (MAC) clinical isolates differed by the expression of hemolytic activity. Two hemolytic MAC strains were less susceptible to the mycobactericidal effect of murine macrophages than two unhemolytic MAC isolates. In vivo, hemolytic MAC bacilli survived in the spleens of infected mice for a longer time than unhemolytic MAC strains. This suggested a role of hemolysins in the virulence of MAC strains. There was no difference in the cytotoxicity of T cells from mice immunized with M. bovis BCG towards macrophages infected in vitro with MAC strains expressing or not expressing hemolytic activity.

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页码：357 / 363

页数：7

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