Reductive cleavage of resin bound arylsulfonates

被引：30

作者：

Jin, SJ ^{[1
]}

Holub, DP ^{[1
]}

Wustrow, DJ ^{[1
]}

机构：

[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Dept Chem, Ann Arbor, MI 48105 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

solid-phase synthesis; sulfonic acid and derivatives; reduction;

D O I：

10.1016/S0040-4039(98)00640-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 4-hydroxybenzoate was tethered to a solid support via an arylsulfonate bond. The carboxylate functionality was converted to a variety of esters and amides. The products were then liberated from the resin by Pd(0) catalyzed reductive cleavage of the arylsulfonate oxygen. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3651 / 3654

页数：4

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