Cell-mediated immune response to influenza vaccination in lung transplant recipients

被引:30
作者
Mazzone, PJ
Mossad, SB
Mawhorter, SD
Mehta, AC
Mauer, JR
机构
[1] Cleveland Clin Fdn, Dept Pulm & Crit Care Med, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Infect Dis, Cleveland, OH 44195 USA
[3] Cigna Healthcare, Hartford, CT USA
关键词
D O I
10.1016/j.healun.2003.08.033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Lung transplant recipients are susceptible to complications from influenza infection. Antibody responses to influenza vaccination have been shown to be decreased in lung transplant recipients. Cellular immune mechanisms serve an important role in influenza clearance. The cellular immune response to influenza vaccination has not been studied in transplant populations. Methods: Interleukin-2, interleukin-10, interferon-gamma, and granzyme B levels to the three viral antigens included in the 1999 to 2000 influenza vaccine were measured before and 4 weeks post-vaccination in 43 lung transplant recipients and 21 healthy adult controls. Results: Interleukin-2, interleukin-10, interferon-gamma, and granzyme B levels did not increase from pre- to post-vaccination in the lung transplant group. Both pre- and post-cytokine levels were lower in the transplant group compared to the. control group. Pre- and post-granzyme B levels did not differ significantly between the groups. The T-helper response in the control group varied with the different viral strains. A correlation between acute rejection episodes and the absence of both azathioprine and mycophenolate was found. Conclusions: Influenza vaccination does not stimulate a cell-mediated immune response in lung transplant recipients as judged by interleukin-2, interleukin-10, interferon-gamma, and granzyme B levels. Alternative prevention strategies may be needed.
引用
收藏
页码:1175 / 1181
页数:7
相关论文
共 45 条
[31]   ANTIBODY-RESPONSE TO INFLUENZA VACCINATION IN RENAL-TRANSPLANT PATIENTS - CORRELATION WITH ALLOGRAFT FUNCTION [J].
PABICO, RC ;
DOUGLAS, RG ;
BETTS, RF ;
MCKENNA, BA ;
FREEMAN, RB .
ANNALS OF INTERNAL MEDICINE, 1976, 85 (04) :431-436
[32]   Influenza vaccines - A reappraisal of their use [J].
Palache, AM .
DRUGS, 1997, 54 (06) :841-856
[33]   DETERMINANTS OF IMMUNITY TO INFLUENZA INFECTION IN MAN [J].
POTTER, CW ;
OXFORD, JS .
BRITISH MEDICAL BULLETIN, 1979, 35 (01) :69-75
[34]   Humoral and cellular immune responses following vaccination with purified recombinant hemagglutinin from influenza A (H3N2) virus [J].
Powers, DC ;
McElhaney, JE ;
Florendo, OA ;
Manning, MC ;
Upshaw, CM ;
Bentley, DW ;
Wilkinson, BE .
JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (02) :342-351
[35]   Suppression of the humoral immune response by mycophenolate mofetil [J].
Smith, KGC ;
Isbel, NM ;
Catton, MG ;
Leydon, JA ;
Becker, GJ ;
Walker, RG .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (01) :160-164
[36]  
Soesman NMR, 2000, J MED VIROL, V61, P85, DOI 10.1002/(SICI)1096-9071(200005)61:1&lt
[37]  
85::AID-JMV14&gt
[38]  
3.0.CO
[39]  
2-H
[40]   IMPAIRED SERUM ANTIBODY-RESPONSE TO INACTIVATED INFLUENZA-A AND INFLUENZA-B VACCINE IN RENAL-TRANSPLANT RECIPIENTS [J].
STIVER, HG ;
GRAVES, P ;
MEIKLEJOHN, G ;
SCHROTER, G ;
EICKHOFF, TC .
INFECTION AND IMMUNITY, 1977, 16 (03) :738-741