Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population

被引：33

作者：

Satake, Wataru

Mizuta, Ikuko

Suzuki, Satoko

Nakabayashi, Yuko

Ito, Chiyomi

Watanabe, Masahiko

Takeda, Atsushi

Hasegawa, Kazuko

Sakoda, Saburo

Yamamoto, Mitsutoshi

Hattori, Nobutaka

Murata, Miho

Toda, Tatsushi

机构：

[1] Osaka Univ, Grad Sch Med, Dept Med Genet, Div Clin Genet, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Neurol, Suita, Osaka 565, Japan

[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Japan

[4] Univ Tsukuba, Inst Clin Med, Dept Neurol, Tsukuba, Ibaraki 305, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Neurosci, Div Neurol, Sendai, Miyagi 980, Japan

[6] Sagamihara Natl Hosp, Natl Hosp Org, Dept Neurol, Sagamihara, Kanagawa, Japan

[7] Kagawa Prefectural Cent Hosp, Dept Neurol, Takamatsu, Kagawa, Japan

[8] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan

[9] Musashi Hosp, Natl Ctr Neurol & Psychiat, Dept Neurol, Kodaira, Tokyo, Japan

来源：

NEUROREPORT | 2007年 / 18卷 / 09期

关键词：

association; case-control study; fibroblast growth factor 20 (FGF20); Parkinson's disease; single nucleotide polymorphism; susceptibility gene;

D O I：

10.1097/WNR.0b013e328133265b

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC + CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.

引用

页码：937 / 940

页数：4

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