Characterization of paracetamol agglomerates by image analysis and strength measurement

被引：46

作者：

Ålander, EM ^{[1
]}

Uusi-Penttilä, MS ^{[1
]}

Rasmuson, ÅC ^{[1
]}

机构：

[1] Royal Inst Technol, Dept Chem Engn & Technol, SE-10044 Stockholm, Sweden

来源：

POWDER TECHNOLOGY | 2003年 / 130卷 / 1-3期

关键词：

crystallization; agglomeration; image analysis; PCA; crushing strength;

D O I：

10.1016/S0032-5910(02)00208-5

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：298 / 306

页数：9

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