Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome P450 monooxygenase

被引：64

作者：

He, J ^{[1
]}

Müller, M ^{[1
]}

Hertweck, C ^{[1
]}

机构：

[1] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 51期

关键词：

D O I：

10.1021/ja046104h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The polyketide antibiotic aureothin, produced by Streptomyces thioluteus, is equipped with a rare exomethylene-tetrahydrofuran moiety. Cloning, heterologous expression, and inactivation experiments reveal that AurH, a bifunctional cytochrome P450 monooxygenase, is required and sufficient for the stereoselective synthesis of the furan ring, involving the subsequent formation of two new C-O bonds. Copyright © 2004 American Chemical Society.

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页码：16742 / 16743

页数：2

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