In-vivo imaging of Alzheimer disease β-amyloid with [11C]SB-13 PET

被引:314
作者
Verhoeff, NPLG
Wilson, AA
Takeshita, S
Trop, L
Hussey, D
Singh, K
Kung, HF
Kung, MP
Houle, S
机构
[1] Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada
[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
关键词
D O I
10.1176/appi.ajgp.12.6.584
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: In-vivo imaging of beta-amyloidplaques (Abeta) may improve both early detection of Alzheimer disease (AD) and efficacy assessment of new treatments for AD. The authors' aim was to develop a novel Abeta-specific positron-emission tomography (PET) tracer Methods: Five female AD patients (54-77 years old) and six healthy female comparison subjects (53-74 years old), completed 2-hour PET scans after intravenous injection of 10 mCi of both the stilbene [C-11]SB-13 and the benzothiazole [C-11]6-OH-BTA-1 (also known as [C-11]PIB). Kinetic analyses were performed on the resulting time-activity curves to derive Abeta binding-potential estimates, using as input function either the unmetabolized tracer concentration in venous plasma from a two-tissue compartment model or the density of radioactivity in the cerebellum. Authors compared the binding characteristics of the two radiotracers. Results: The two radiotracers demonstrated similar binding properties with respect to regional distribution of retention (increased retention in the frontal and posterior temporal-inferior parietal association cortices in the AD patients, but not in the comparison subjects). Our preliminary PET data indicate that [C-11]SB-13 may be similar to [C-11]PIB in discriminating AD patients from comparison subjects. Conclusions: [C-11]SB-13 is an effective PET tracer for fibrillar Abeta imaging in vivo, with similar performance as [C-11]PIB. Future research directions include evaluation of tracer in larger AD patient samples and in subjects with amnestic mild cognitive impairment, evaluation of arterial input function, and comparison with other tracers, such as [F-18]FDG as they relate to cognitive functioning.
引用
收藏
页码:584 / 595
页数:12
相关论文
共 47 条
[21]   Human amyloid-imaging studies in controls, mild cognitive impairment and Alzheimer's disease using Pittsburgh compound-B [J].
Klunk, WE ;
Price, JC ;
Lopresti, BJ ;
Debnath, ML ;
Holt, DP ;
Wang, YM ;
Huang, GF ;
Shao, L ;
Meltzer, C ;
DeKosky, ST ;
Mathis, CA .
NEUROBIOLOGY OF AGING, 2004, 25 :S58-S58
[22]   Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B [J].
Klunk, WE ;
Engler, H ;
Nordberg, A ;
Wang, YM ;
Blomqvist, G ;
Holt, DP ;
Bergström, M ;
Savitcheva, I ;
Huang, GF ;
Estrada, S ;
Ausén, B ;
Debnath, ML ;
Barletta, J ;
Price, JC ;
Sandell, J ;
Lopresti, BJ ;
Wall, A ;
Koivisto, P ;
Antoni, G ;
Mathis, CA ;
Långström, B .
ANNALS OF NEUROLOGY, 2004, 55 (03) :306-319
[23]   Binding of two potential imaging agents targeting amyloid plaques in Alzheimer's disease brains [J].
Kung, MP ;
Hou, C ;
Zhuang, ZP ;
Skovronsky, DM ;
Kung, HF .
NEUROBIOLOGY OF AGING, 2004, 25 :S57-S57
[24]   Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease [J].
Kung, MP ;
Hou, C ;
Zhuang, ZP ;
Skovronsky, D ;
Kung, HF .
BRAIN RESEARCH, 2004, 1025 (1-2) :98-105
[25]   Simplified reference tissue model for PET receptor studies [J].
Lammertsma, AA ;
Hume, SP .
NEUROIMAGE, 1996, 4 (03) :153-158
[26]   A strategy for removing the bias in the graphical analysis method [J].
Logan, J ;
Fowler, JS ;
Volkow, ND ;
Ding, YS ;
Wang, GJ ;
Alexoff, DL .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (03) :307-320
[27]   The end of world population growth [J].
Lutz, W ;
Sanderson, W ;
Scherbov, S .
NATURE, 2001, 412 (6846) :543-545
[28]  
MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[29]   A JAVA']JAVA environment for medical image data analysis: initial application for brain PET quantitation [J].
Mikolajczyk, K ;
Szabatin, M ;
Rudnicki, P ;
Grodzki, M ;
Burger, C .
MEDICAL INFORMATICS, 1998, 23 (03) :207-214
[30]   11C-labeled stilbene derivatives as Aβ-aggregate-specific PET imaging agents for Alzheimer's disease [J].
Ono, M ;
Wilson, A ;
Nobrega, J ;
Westaway, D ;
Verhoeff, P ;
Zhuang, ZP ;
Kung, MP ;
Kung, HF .
NUCLEAR MEDICINE AND BIOLOGY, 2003, 30 (06) :565-571