Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana

被引：23

作者：

Liaw, CC

Chang, FR

Wu, CC

Chen, SL

Bastow, KF

Hayashi, KI

Nozaki, H

Lee, KH

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Univ N Carolina, Nat Prod Lab, Sch Pharm, Chapel Hill, NC USA

[3] Okayama Univ Sci, Dept Biochem, Fac Sci, Okayama, Japan

来源：

PLANTA MEDICA | 2004年 / 70卷 / 10期

关键词：

Annona montana; Annonaceae; montalicin; Annonaceous acetogenins; human hepatoma cell; cytotoxicity;

D O I：

10.1055/s-2004-832622

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine monotetrahydrofuranic Annonaceous acetogenins, montalicins A - E (1 - 5), cis-annoreticuin (6), montalicins F (7), 1 (8), and J (9), along with eight known acetogenins 10-17, were isolated from the seeds of Annona montana by a high performance liquid chromatographic (HPLC) method. The structures of all new isolates were elucidated and characterized by spectro-scopic and chemical methods. These monotetrahydrofuranic Annonaceous acetogenins showed selectively potent cytotoxicity against two human cancer cell lines, 1A9 and Hep G2.

引用

页码：948 / 959

页数：12

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