HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

被引：130

作者：

del Rio, M. L. ^{[1
]}

Lucas, C. L. ^{[2
]}

Buhler, L. ^{[2
,3
]}

Rayat, G. ^{[4
]}

Rodriguez-Barbosa, J. I. ^{[1
]}

机构：

[1] Inst Biomed, Immunobiol Lab, Leon, Spain

[2] Harvard Univ, Massachusetts Gen Hosp, Bone Marrow Transplantat Sect,Sch Med, Transplantat Biol Res Ctr, Boston, MA USA

[3] Univ Hosp Geneva, Dept Surg, Surg Res Unit, Geneva, Switzerland

[4] Univ Alberta, Fac Med & Dent, Alberta Diabet Inst, Edmonton, AB, Canada

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 02期

关键词：

coinhibition; costimulation; transplantation; autoimmunity; T-LYMPHOCYTE ATTENUATOR; HERPESVIRUS ENTRY MEDIATOR; FACTOR RECEPTOR SUPERFAMILY; LYMPHOTOXIN-BETA RECEPTOR; MHC CLASS-I; B-LYMPHOCYTE; CELL-ACTIVATION; TNF SUPERFAMILY; FAMILY-MEMBER; NK CELLS;

D O I：

10.1189/jlb.0809590

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threatening infections and is associated with organ toxicity when used long-term. Thus, alternative approaches that inhibit only the unwanted immune responses and preserve general immunity are highly desirable. The receptor/ligand pairs involved in the cross-talk between DC and T cells have been the focus of intense and exciting research during the last decade. The HVEM/LIGHT/BTLA/CD160 costimulatory/coinhibitory pathway has emerged as a potential target for the development of immune therapeutic interventions. Herein, we will summarize and discuss how blockade of the costimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses. J. Leukoc. Biol. 87: 223-235; 2010.

引用

收藏

页码：223 / 235

页数：13

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