Preparation and study on the solid inclusion complex of sparfloxacin with HP-β-cyclodextrin

被引：16

作者：

Chao, JB ^{[1
]}

Li, JS ^{[1
]}

Meng, DP ^{[1
]}

Huang, SP ^{[1
]}

机构：

[1] Shanxi Univ, Test & Anal Ctr, Taiyuan 030006, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 04期

关键词：

sparfloxacin; HP-beta-CD; inclusion complex; ID NMR; 2D NMR;

D O I：

10.1016/S1386-1425(02)00236-6

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The interaction of sparfloxacin with HP-beta-cyclodextrin (HP-beta-CD) has been studied by several analytical techniques, including H-1 NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis and scanning electron microscopy. In this paper, solid inclusion complex of sparfloxacin with HP-beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared, differential scanning calorimetry and ID, 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of sparfloxacin with HP-beta-CD. The formation constant of complex was determined by the fluorescence method and H-1 NMR. Spacial configuration of complex has been proposed on 2D NMR technique. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：705 / 711

页数：7

共 30 条

[11] CYCLODEXTRIN-INDUCED FLUID SOLUTION ROOM-TEMPERATURE PHOSPHORESCENCE FROM ACENAPHTHENE IN THE PRESENCE OF 2-BROMOETHANOL [J].

DELAPENA, AM ;

DURANMERAS, I ;

SALINAS, F .

ANALYTICA CHIMICA ACTA, 1991, 255 (02) :351-357

[12]

DUCHENE D, 1988, P 4 INT S CYCL, P265

[13] SPECTROFLUOROMETRIC DETERMINATION OF NALIDIXIC-ACID BASED ON HOST-GUEST COMPLEXATION WITH GAMMA-CYCLODEXTRIN [J].

DURANMERAS, I ;

DELAPENA, AM ;

SALINAS, F ;

CACERES, IR .

ANALYST, 1994, 119 (06) :1215-1219

[14] Spectrofluorimetric determination of piroxicam in the presence and absence of β-cyclodextrin [J].

Escandar, GM .

ANALYST, 1999, 124 (04) :587-591

[15] Room-temperature phosphorescence of acenaphthene in aerated solutions in the presence of bromoalcohols and γ-cyclodextrin [J].

Escandar, GM ;

de la Pena, AM .

ANALYTICA CHIMICA ACTA, 1998, 370 (2-3) :199-205

[16]

HURTUBISE RJ, 1990, PHOSPHORIMETRY THEOR, P320

[17] Interactions of ketoprofen and ibuprofen with β-cyclodextrins in solution and in the solid state [J].

Mura, P ;

Bettinetti, GP ;

Manderioli, A ;

Faucci, MT ;

Bramanti, G ;

Sorrenti, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 166 (02) :189-203

[18]

Nelson G, 1986, J SPECTROSC, V3, P24

[19] INVESTIGATION OF THE BETA-CYCLODEXTRIN INDOLE INCLUSION COMPLEX BY ABSORPTION AND FLUORESCENCE SPECTROSCOPIES [J].

ORSTAN, A ;

ROSS, JBA .

JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (11) :2739-2745

[20]

Scyrinski S., 1984, ANAL CHEM, V46, P331

← 1 2 3 →