Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents

被引：72

作者：

Dinman, JD

Ruiz-Echevarria, MJ

Peltz, SW

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Grad Program Mol Biosci, Piscataway, NJ 08854 USA

[3] Canc Inst New Jersey, Piscataway, NJ 08854 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 04期

关键词：

D O I：

10.1016/S0167-7799(97)01167-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production, Ribosomal frameshifting therefore provides a unique target on which antiviral agents can function, This article describes a series of rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed -1 ribosomal frameshifting.

引用

页码：190 / 196

页数：7

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