Interleukin 18 in the CNS

被引：234

作者：

Alboni, Silvia ^{[2
]}

Cervia, Davide ^{[3
]}

Sugama, Shuei ^{[4
]}

Conti, Bruno ^{[1
]}

机构：

[1] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA

[2] Univ Modena & Reggio Emilia, Dept Biomed Sci, Modena, Italy

[3] Univ Tuscia, Dept Environm Sci, Viterbo, Italy

[4] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

JOURNAL OF NEUROINFLAMMATION | 2010年 / 7卷

关键词：

CENTRAL-NERVOUS-SYSTEM; GAMMA-INDUCING FACTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; RAT DENTATE GYRUS; LONG-TERM POTENTIATION; NECROSIS-FACTOR-ALPHA; SEMLIKI-FOREST-VIRUS; IFN-GAMMA; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS;

D O I：

10.1186/1742-2094-7-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.

引用

页数：12

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