A novel core-shell type polymer support for solid-phase peptide synthesis

被引：22

作者：

Cho, JK

Park, BD

Lee, YS ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Chem Engn, Seoul 151742, South Korea

[2] Aekyung Cent Res Ctr, Taejeon 300200, South Korea

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)01279-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel core-shell type resins with a highly cross-linked polystyrene (PS) core and a poly(ethylene glycol) (PEG) shell were prepared by suspension polymerization for use in solid-phase synthesis. All the resins were of bead type with a diameter of 50-200 mu m. The loading capacities of the amino groups were 0.05-0.2 mmol/g resin and the thickness of the PEG shell was 2-4 mu m. Compared with the other resins such as 1% cross-linked PS resin and TentaGel resin, the resins showed excellent performance in photolytic release of peptide product from photolabile linker. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：7481 / 7485

页数：5

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