The effects of metabolic syndrome Versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events

被引:13
作者
Dai, Dao-Fu
Lin, Jou-Wei
Kao, Jia-Horng
Hsu, Chih-Neng
Chiang, Fu-Tien
Lin, Jiunn-Lee
Chou, Yi-Hua
Hsu, Kwan-Lih
Tseng, Chuen-Den
Tseng, Yung-Zu
Hwang, Juey-Jen
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiovasc, Taipei 100, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Internal Med, Div Gastroenterol, Taipei 100, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan
[4] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 100, Taiwan
[5] Natl Taiwan Univ Hosp, Ctr Cardiovasc, Dou Liou City 640, Yun Lin, Taiwan
关键词
D O I
10.1210/jc.2006-2428
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P < 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.
引用
收藏
页码:2532 / 2537
页数:6
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