New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii

被引：25

作者：

Roccatagliata, AJ ^{[1
]}

Maier, MS ^{[1
]}

Seldes, AM ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 03期

关键词：

D O I：

10.1021/np970429c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2 beta,3 alpha,21-triol 2,21-disulfate (1), (20R)-5 alpha-cholest-24-ene-2 beta,3 alpha,21-triol 3,21-disulfate (3), and (20R)-cholesta-5,24-diene-2 alpha,3 alpha,4 beta,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3 beta-ol, cholesta-5,24-dien-3 beta-ol and (22E) cholesta-5,22-dien-3 beta-ol as the major sterols.

引用

页码：370 / 374

页数：5

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