Mapping functional residues onto integrin crystal structures

被引：59

作者：

Humphries, MJ ^{[1
]}

Symonds, EJH ^{[1
]}

Mould, AP ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0959-440X(03)00035-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Historical data, available in the literature, concerning the sites responsible for integrin-ligand binding and activation may now be transposed onto recently solved crystal structures of integrin dimers and functional domains. The data were obtained through studies of natural and engineered mutations within integrins, and analyses of the epitopes for function-altering monoclonal antibodies. In the past two years, this combining of structure and function has led to the development of, novel hypotheses for the mechanisms of integrin regulation.

引用

页码：236 / 243

页数：8

共 50 条

[1] Coming to grips with integrin binding to ligands [J].

Arnaout, MA ;

Goodman, SL ;

Xiong, JP .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (05) :641-651

[2] BETA(2) (CD18) MUTATIONS ABOLISH LIGAND RECOGNITION BY I-DOMAIN INTEGRINS LFA-1 (ALPHA(L)BETA(2), CD11A/CD18) AND MAC-1 (ALPHA(M)BETA(2), CD11B/CD18) [J].

BAJT, ML ;

GOODMAN, T ;

MCGUIRE, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) :94-98

[3]

BAJT ML, 1994, J BIOL CHEM, V269, P20913

[4] Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation [J].

Beglova, N ;

Blacklow, SC ;

Takagi, J ;

Springer, TA .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (04) :282-287

[5] Fine mapping of inhibitory anti-α5 monoclonal antibody epitopes that differentially affect integrin-ligand binding [J].

Burrows, L ;

Clark, K ;

Mould, AP ;

Humphries, MJ .

BIOCHEMICAL JOURNAL, 1999, 344 :527-533

[6] FURTHER-STUDIES ON THE TOPOGRAPHY OF THE N-TERMINAL REGION OF HUMAN PLATELET GLYCOPROTEIN-IIIA - LOCALIZATION OF MONOCLONAL-ANTIBODY EPITOPES AND THE PUTATIVE FIBRINOGEN-BINDING SITES [J].

CALVETE, JJ ;

ARIAS, J ;

ALVAREZ, MV ;

LOPEZ, MM ;

HENSCHEN, A ;

GONZALEZRODRIGUEZ, J .

BIOCHEMICAL JOURNAL, 1991, 274 :457-463

[7] FURTHER-STUDIES ON THE TOPOGRAPHY OF HUMAN PLATELET GLYCOPROTEIN-IIB - LOCALIZATION OF MONOCLONAL-ANTIBODY EPITOPES AND THE PUTATIVE GLYCOPROTEIN IIIA- AND FIBRINOGEN-BINDING REGIONS [J].

CALVETE, JJ ;

ARIAS, J ;

ALVAREZ, MV ;

LOPEZ, MM ;

HENSCHEN, A ;

GONZALEZRODRIGUEZ, J .

BIOCHEMICAL JOURNAL, 1991, 273 :767-775

[8] Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1 [J].

Edwards, CP ;

Fisher, KL ;

Presta, LG ;

Bodary, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (44) :28937-28944

[9] Structural basis of collagen recognition by integrin α2β1 [J].

Emsley, J ;

Knight, CG ;

Farndale, RW ;

Barnes, MJ ;

Liddington, RC .

CELL, 2000, 101 (01) :47-56

[10] The molecular genetics of Glanzmann's thrombasthenia [J].

French, DL .

PLATELETS, 1998, 9 (01) :5-20

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