A fuzzy gene expression-based computational approach improves breast cancer prognostication

被引：43

作者：

Haibe-Kains, Benjamin ^{[1
,2
]}

Desmedt, Christine ^{[1
]}

Rothe, Francoise ^{[1
]}

Piccart, Martine ^{[1
]}

Sotiriou, Christos ^{[1
]}

Bontempi, Gianluca ^{[2
]}

机构：

[1] Inst Jules Bordet, Dept Med Oncol, Funct Genom & Translat Res Unit, B-1000 Brussels, Belgium

[2] Univ Libre Bruxelles, Dept Comp Sci, Machine Learning Grp, B-1050 Brussels, Belgium

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 02期

关键词：

MOLECULAR PORTRAITS; ADJUVANT THERAPY; SIGNATURE; VALIDATION; PROGNOSIS; METASTASIS; SURVIVAL; CLASSIFICATION; CHEMOTHERAPY; PROFILES;

D O I：

10.1186/gb-2010-11-2-r18

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Early gene expression studies classified breast tumors into at least three clinically relevant subtypes. Although most current gene signatures are prognostic for estrogen receptor (ER) positive/human epidermal growth factor receptor 2 (HER2) negative breast cancers, few are informative for ER negative/HER2 negative and HER2 positive subtypes. Here we present Gene Expression Prognostic Index Using Subtypes (GENIUS), a fuzzy approach for prognostication that takes into account the molecular heterogeneity of breast cancer. In systematic evaluations, GENIUS significantly outperformed current gene signatures and clinical indices in the global population of patients.

引用

页数：18

共 67 条

[1]

[Anonymous], ADJ ONL DEC MAK TOOL

[2]

BABUSKA R, 1996, THESIS TU DELFT

[3] Oncogenic pathway signatures in human cancers as a guide to targeted therapies [J].

Bild, AH ;

Yao, G ;

Chang, JT ;

Wang, QL ;

Potti, A ;

Chasse, D ;

Joshi, MB ;

Harpole, D ;

Lancaster, JM ;

Berchuck, A ;

Olson, JA ;

Marks, JR ;

Dressman, HK ;

West, M ;

Nevins, JR .

NATURE, 2006, 439 (7074) :353-357

[4] RETRACTED: Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial (Retracted Article. See vol 12, pg 116, 2011) [J].

不详 .

LANCET ONCOLOGY, 2007, 8 (12) :1071-1078

[5]

BONTEMPI G, 1999, THESIS U LIBRE BRUXE

[6] Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer [J].

Buyse, Marc ;

Loi, Sherene ;

van't Veer, Laura ;

Viale, Giuseppe ;

Delorenzi, Mauro ;

Glas, Annuska M. ;

d'Assignies, Mahasti Saghatchian ;

Bergh, Jonas ;

Lidereau, Rosette ;

Ellis, Paul ;

Harris, Adrian ;

Bogaerts, Jan ;

Therasse, Patrick ;

Floore, Arno ;

Amakrane, Mohamed ;

Piette, Fanny ;

Rutgers, Emiel ;

Sotiriou, Christos ;

Cardoso, Fatima ;

Piccart, Martine J. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (17) :1183-1192

[7] Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer [J].

Calabro, Alberto ;

Beissbarth, Tim ;

Kuner, Ruprecht ;

Stojanov, Michael ;

Benner, Axel ;

Asslaber, Martin ;

Ploner, Ferdinand ;

Zatloukal, Kurt ;

Samonigg, Hellmut ;

Poustka, Annemarie ;

Sueltmann, Holger .

BREAST CANCER RESEARCH AND TREATMENT, 2009, 116 (01) :69-77

[8] Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients [J].

Calza, Stefano ;

Hall, Per ;

Auer, Gert ;

Bjohle, Judith ;

Klaar, Sigrid ;

Kronenwett, Ulrike ;

T Liu, Edison ;

Miller, Lance ;

Ploner, Alexander ;

Smeds, Johanna ;

Bergh, Jonas ;

Pawitan, Yudi .

BREAST CANCER RESEARCH, 2006, 8 (04)

[9] Prediction of metastatic relapse in node-positive breast cancer:: establishment of a clinicogenomic model after FEC100 adjuvant regimen [J].

Campone, Mario ;

Campion, Loic ;

Roche, Henry ;

Gouraud, Wilfried ;

Charbonnel, Catherine ;

Magrangeas, Florence ;

Minvielle, Stephane ;

Geneve, Jean ;

Martin, Anne-Laure ;

Bataille, Regis ;

Jezequel, Pascal .

BREAST CANCER RESEARCH AND TREATMENT, 2008, 109 (03) :491-501

[10] The MINDACT trial: The first prospective clinical validation of a genomic tool [J].

Cardoso, Fatima ;

Piccart-Gebhart, Martine ;

Van't Veer, Laura ;

Rutgers, Emiel .

MOLECULAR ONCOLOGY, 2007, 1 (03) :246-251

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