Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts

被引:61
作者
Park, HG [1 ]
Jeong, BS
Yoo, MS
Lee, JH
Park, BS
Kim, MG
Jew, SS
机构
[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
关键词
D O I
10.1016/S0040-4039(03)00687-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them, the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97 to >99% ee). (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3497 / 3500
页数:4
相关论文
共 16 条