Speckle reduction in optical coherence tomography by "path length encoded" angular compounding

被引:136
作者
Iftimia, N
Bouma, BE
Tearney, GJ
机构
[1] Harvard Univ, Sch Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Wellman Labs Photomed, Dept Pathol, Boston, MA 02114 USA
关键词
speckle reduction; optical coherence tomography; catheters; endoscopes;
D O I
10.1117/1.1559060
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Speckle, the dominant factor reducing image quality in optical coherence tomography (OCT), limits the ability to identify cellular structures that are essential for diagnosis of a variety of diseases. We describe a new high-speed method for implementing angular compounding by path length encoding (ACPE) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and requires minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased SNR that correlates well with theory. (C) 2003 Society of Photo-Optical Instrumentation Engineers.
引用
收藏
页码:260 / 263
页数:4
相关论文
共 11 条
[1]   Statistics and reduction of speckle in optical coherence tomography [J].
Bashkansky, M ;
Reintjes, J .
OPTICS LETTERS, 2000, 25 (08) :545-547
[2]   Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography [J].
Bouma, BE ;
Tearney, GJ ;
Bilinsky, IP ;
Golubovic, B ;
Fujimoto, JG .
OPTICS LETTERS, 1996, 21 (22) :1839-1841
[3]   Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography [J].
Bouma, BE ;
Tearney, GJ .
OPTICS LETTERS, 1999, 24 (08) :531-533
[4]   High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography [J].
Bouma, BE ;
Tearney, GJ ;
Compton, CC ;
Nishioka, NS .
GASTROINTESTINAL ENDOSCOPY, 2000, 51 (04) :467-474
[5]   All-solid-state Cr:forsterite laser generating 14-fs pulses at 1.3 μm [J].
Chudoba, C ;
Fujimoto, JG ;
Ippen, EP ;
Haus, HA ;
Morgner, U ;
Kärtner, FX ;
Scheuer, V ;
Angelow, G ;
Tschudi, T .
OPTICS LETTERS, 2001, 26 (05) :292-294
[6]   High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS [J].
Das, A ;
Sivak, MV ;
Chak, A ;
Wong, RCK ;
Westphal, V ;
Rollins, AM ;
Willis, J ;
Isenberg, G ;
Izatt, JA .
GASTROINTESTINAL ENDOSCOPY, 2001, 54 (02) :219-224
[7]   Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound [J].
Jang, IK ;
Bouma, BE ;
Kang, DH ;
Park, SJ ;
Park, SW ;
Seung, KB ;
Choi, KB ;
Shishkov, M ;
Schlendorf, K ;
Pomerantsev, E ;
Houser, SL ;
Aretz, HT ;
Tearney, GJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) :604-609
[8]   Optimal interferometer designs for optical coherence tomography [J].
Rollins, AM ;
Izatt, JA .
OPTICS LETTERS, 1999, 24 (21) :1484-1486
[9]   Array detection for speckle reduction in optical coherence microscopy [J].
Schmitt, JM .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (07) :1427-1439
[10]   Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography [J].
Tearney, GJ ;
Boppart, SA ;
Bouma, BE ;
Brezinski, ME ;
Weissman, NJ ;
Southern, JF ;
Fujimoto, JG .
OPTICS LETTERS, 1996, 21 (07) :543-545