Interferon α and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS

被引:165
作者
Zagury, D
Lachgar, A
Chams, V
Fall, LS
Bernard, J
Zagury, JF
Bizzini, B
Gringeri, A
Santagostino, E
Rappaport, J
Feldman, M
Burny, A
Gallo, RC
机构
[1] Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA
[2] Inst Jean Godinoi, F-51100 Reims, France
[3] Univ Pierre & Marie Curie, Paris, France
[4] Univ Milan, I-20122 Milan, Italy
[5] Maggiore Hosp, IRCCS, A Bianchi Bonomi Hemophilia & Thrombosis Ctr, Bologna, Italy
[6] Allegheny Univ Hlth Sci, Ctr Neurovirol & Neurooncol, Philadelphia, PA 19102 USA
[7] Univ Libre Bruxelles, B-1050 Brussels, Belgium
[8] Weizmann Inst Sci, IL-76100 Rehovot, Israel
关键词
D O I
10.1073/pnas.95.7.3851
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
HIV type 1 (HIV-1) not only directly kills infected CD4(+) T cells but also induces immunosuppression of uninfected T cells, Two immunosuppressive proteins, interferon alpha (IFN alpha) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV 1-infected peripheral blood mononuclear cell cultures, Furthermore, the production of C-C chemokines in response to immune cell activation, initially enhanced by IFN alpha and Tat, ultimately is inhibited by these proteins in parallel with their induction of immunosuppression, The clinical corollary is the immunosuppression of uninfected T cells and the decline in C-C chemokine release found at advanced stages of HIV-1 infection paralleling rising levels of IFN alpha and extracellular Tat, We, therefore, suggest that IFN alpha and Tat may be critical targets for anti-AIDS strategies.
引用
收藏
页码:3851 / 3856
页数:6
相关论文
共 44 条
  • [11] RESTORATION OF HIV-SPECIFIC CELL-MEDIATED IMMUNE-RESPONSES BY INTERLEUKIN-12 IN-VITRO
    CLERICI, M
    LUCEY, DR
    BERZOFSKY, JA
    PINTO, LA
    WYNN, TA
    BLATT, SP
    DOLAN, MJ
    HENDRIX, CW
    WOLF, SF
    SHEARER, GM
    [J]. SCIENCE, 1993, 262 (5140) : 1721 - 1724
  • [12] DETECTION OF 3 DISTINCT PATTERNS OF T-HELPER CELL DYSFUNCTION IN ASYMPTOMATIC, HUMAN IMMUNODEFICIENCY VIRUS-SEROPOSITIVE PATIENTS - INDEPENDENCE OF CD4+ CELL NUMBERS AND CLINICAL STAGING
    CLERICI, M
    STOCKS, NI
    ZAJAC, RA
    BOSWELL, RN
    LUCEY, DR
    VIA, CS
    SHEARER, GM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) : 1892 - 1899
  • [13] IDENTIFICATION OF RANTES, MIP-1-ALPHA, AND MIP-1-BETA AS THE MAJOR HIV-SUPPRESSIVE FACTORS PRODUCED BY CD8(+) T-CELLS
    COCCHI, F
    DEVICO, AL
    GARZINODEMO, A
    ARYA, SK
    GALLO, RC
    LUSSO, P
    [J]. SCIENCE, 1995, 270 (5243) : 1811 - 1815
  • [14] Identification of a major co-receptor for primary isolates of HIV-1
    Deng, HK
    Liu, R
    Ellmeier, W
    Choe, S
    Unutmaz, D
    Burkhart, M
    DiMarzio, P
    Marmon, S
    Sutton, RE
    Hill, CM
    Davis, CB
    Peiper, SC
    Schall, TJ
    Littman, DR
    Landau, NR
    [J]. NATURE, 1996, 381 (6584) : 661 - 666
  • [15] HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5
    Dragic, T
    Litwin, V
    Allaway, GP
    Martin, SR
    Huang, YX
    Nagashima, KA
    Cayanan, C
    Maddon, PJ
    Koup, RA
    Moore, JP
    Paxton, WA
    [J]. NATURE, 1996, 381 (6584) : 667 - 673
  • [16] SYNERGY BETWEEN BASIC FIBROBLAST GROWTH-FACTOR AND HIV-I TAT PROTEIN IN INDUCTION OF KAPOSIS-SARCOMA
    ENSOLI, B
    GENDELMAN, R
    MARKHAM, P
    FIORELLI, V
    COLOMBINI, S
    RAFFELD, M
    CAFARO, A
    CHANG, HK
    BRADY, JN
    GALLO, RC
    [J]. NATURE, 1994, 371 (6499) : 674 - 680
  • [17] TAT PROTEIN OF HIV-1 STIMULATES GROWTH OF CELLS DERIVED FROM KAPOSIS-SARCOMA LESIONS OF AIDS PATIENTS
    ENSOLI, B
    BARILLARI, G
    SALAHUDDIN, SZ
    GALLO, RC
    WONGSTAAL, F
    [J]. NATURE, 1990, 345 (6270) : 84 - 86
  • [18] HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor
    Feng, Yu
    Broder, Christopher C.
    Kennedy, Paul E.
    Berger, Edward A.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (11) : 872 - 877
  • [19] FERBAS JJ, 1994, J IMMUNOL, V152, P4649
  • [20] INTERFERONS IN THE PERSISTENCE, PATHOGENESIS, AND TREATMENT OF HIV-INFECTION
    FRANCIS, ML
    MELTZER, MS
    GENDELMAN, HE
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (02) : 199 - 207