The intrinsic function of a motor system -: from ion channels to networks and behavior

被引:89
作者
Grillner, S [1 ]
Cangiano, L [1 ]
Hu, GY [1 ]
Thompson, R [1 ]
Hill, R [1 ]
Wallén, P [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, Nobel Inst Neurophysiol, SE-17177 Stockholm, Sweden
关键词
locomotion; networks; ion channel; modulation; modeling; behavior;
D O I
10.1016/S0006-8993(00)03088-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The forebrain, brainstem and spinal cord contribution to the control of locomotion is reviewed in this article. The lamprey is used as an experimental model since it allows a detailed cellular analysis of the neuronal network underlying locomotion. The focus is on cellular mechanisms that are important for the pattern generation, as well as different types of pre- and postsynaptic modulation. This experimental model is bridging the gap between the molecular and cellular level to the network and behavioral level. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:224 / 236
页数:13
相关论文
共 80 条
[11]  
BRODIN L, 1989, J NEUROSCI, V9, P3428
[12]   MONOCLONAL-ANTIBODIES AS MAGIC BULLETS [J].
BRODSKY, FM .
PHARMACEUTICAL RESEARCH, 1988, 5 (01) :1-9
[13]   A NEW CLASS OF SMALL INHIBITORY INTERNEURONES IN THE LAMPREY SPINAL-CORD [J].
BUCHANAN, JT ;
GRILLNER, S .
BRAIN RESEARCH, 1988, 438 (1-2) :404-407
[14]   5-HYDROXYTRYPTAMINE DEPRESSES RETICULOSPINAL EXCITATORY POSTSYNAPTIC POTENTIALS IN MOTONEURONS OF THE LAMPREY [J].
BUCHANAN, JT ;
GRILLNER, S .
NEUROSCIENCE LETTERS, 1991, 122 (01) :71-74
[16]   NEWLY IDENTIFIED GLUTAMATE INTERNEURONS AND THEIR ROLE IN LOCOMOTION IN THE LAMPREY SPINAL-CORD [J].
BUCHANAN, JT ;
GRILLNER, S .
SCIENCE, 1987, 236 (4799) :312-314
[17]   GABAB receptor activation inhibits N- and P/Q-type calcium channels in cultured lamprey sensory neurons [J].
Bussières, N ;
El Manira, A .
BRAIN RESEARCH, 1999, 847 (02) :175-185
[18]   CO-LOCALIZED GABA AND SOMATOSTATIN USE DIFFERENT IONIC MECHANISMS TO HYPERPOLARIZE TARGET NEURONS IN THE LAMPREY SPINAL-CORD [J].
CHRISTENSON, J ;
ALFORD, S ;
GRILLNER, S ;
HOKFELT, T .
NEUROSCIENCE LETTERS, 1991, 134 (01) :93-97
[19]  
COHEN AH, 1980, EXP BRAIN RES, V41, P11
[20]   VESTIBULAR CONTROL OF SWIMMING IN LAMPREY .2. CHARACTERISTICS OF SPATIAL SENSITIVITY OF RETICULOSPINAL NEURONS [J].
DELIAGINA, TG ;
ORLOVSKY, GN ;
GRILLNER, S ;
WALLEN, P .
EXPERIMENTAL BRAIN RESEARCH, 1992, 90 (03) :489-498