Synthesis of 4-guanidinopyrimidine nucleosides for triple helix-mediated guanine and cytosine recognition.

被引：23

作者：

Doronina, SO ^{[1
]}

Behr, JP ^{[1
]}

机构：

[1] Univ Strasbourg 1, Fac Pharm Strasbourg, CNRS, Lab Chim Genet, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(97)10627-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recognition of DNA sequences by triple helix-forming oligonucleotides is restricted to homopurine sequences. Based on geometrical considerations, a single nucleoside, 4-guanidinocytidine 1, was designed to recognize both guanosine (as the natural 1 beta anomer) and cytidine (as the 1 alpha anomer) in a new triple helix context where the third strand is centered in the major groove of the target duplex. Several methods of synthesis of this nucleoside are described. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：547 / 550

页数：4

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