The solid phase synthesis of unsymmetrical phosphinic acids

被引：11

作者：

Cox, PB ^{[1
]}

Loh, VM ^{[1
]}

Monteils, C ^{[1
]}

Baxter, AD ^{[1
]}

Boyd, EA ^{[1
]}

机构：

[1] Oxford Asymmetry Int PLC, Discovery Div, Abingdon OX14 4RX, Oxon, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 01期

关键词：

solid phase organic chemistry (SPOC); bis-trimethylsilylphosphonite (BTSP); phosphinic acids;

D O I：

10.1016/S0040-4039(00)01897-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This letter describes a method for the synthesis of unsymmetrical phosphinic acids by the phosphinylation of a resin-bound aldehyde and subsequent 'P' alkylation. This synthetic transformation is very difficult to perform as selectively in solution and therefore further exemplifies the powerful nature of solid phase organic chemistry (SPOC). (C) 2000 Published by Elsevier Science Ltd.

引用

页码：125 / 128

页数：4

共 17 条

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